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Causes of Endometriosis: Coelomic Metaplasia Theory

 
If we explain the pathogenesis of endometriosis according to the theory of endometrial implantation, then where does the focus of endometriosis, such as lung and kidney, come from?
 
In the early 20th century, Meyer put forward the theory of coelomic metaplasia, that is, coelomatous epithelium covering the ovary and pelvic peritoneum. It has tissue homology with endometrium and can be transformed into endometrium under certain stimulation.
 
How it differentiates into olfactory tissue or other special cells in the uterus has not been elucidated, which may be caused by the repeated action of some hormones or the stimulation of menstrual blood and chronic inflammation. Endometriosis occurs in men with prostate cancer treated with estrogen, which strongly supports this theory.
 
Through animal experiments, it has been confirmed that endometrium can be transferred through blood and lymph channels and implanted in some parts far away from the pelvis, such as the nasal cavity, lungs, kidneys, lymph nodes, etc.

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