Endometriosis(EMS) is an estrogen-dependent disease, and estrogen may be one of the factors regulating the expression of these chemokines and their receptors. In addition, environmental factors may also increase the incidence rate of endometriosis. It is found that dioxin can increase the risk of endometriosis in women.
Dioxin is a kind of environmental pollutant which seriously affects human health. It has the characteristics of pox, teratogenesis, immunotoxicity, reproductive toxicity, and endocrine toxicity. Dioxins are by-products produced in the production process, such as paper bleaching, polyethylene plastic production, pesticide Mucun preservative, dry cleaning agent, herbicide production, industrial accidents and metal recovery, exhaust gas from automobile exhaust, especially incineration waste and medical waste.
The ways of dioxin entering the human body are as follows:
1. Absorbed through the digestive tract, which is the main way of human poisoning;
2. Absorbed through the respiratory tract;
3. Absorbed through the skin.
In 1993, Rier and other reports reported the direct relationship between dioxin and the incidence of endometriosis. They found that the incidence rate of endometriosis in Ganges RIver monkeys with chronic dioxin exposure was significantly higher than that of the control group in 4 years, and the severity of disease was positively correlated with exposure dose.
Koninckx et al. reported that the incidence and severity of endometriosis in Belgian women are the highest in the world. The incidence of endometriosis in Belgian women with clinical manifestations of infertility and chronic pelvic pain is 6o-8o, and the concentration of dioxin in the blood is significantly higher than that in non-endometriosis. These are consistent with the serious pollution of dioxin and other environmental toxins in the country.
Mayani, an Israeli scholar, also confirmed that endometriosis is related to the increase of dioxin concentration. They found that TCDD concentration in the blood of women with endometriosis and nonpregnant women was significantly higher than that of women with tubal infertility, which indirectly explained the correlation between the occurrence of endometriosis and dioxin.
Dioxin is not only related to the pathogenesis of endometriosis but also has been found to promote the development of endometriosis. Endometriosis is a common disease that seriously affects women's physical and mental health. Its incidence rate is increasing gradually. And the more and more serious environmental toxins, dioxins and endosperm, are at least partly explained. However, the exact relationship between the two needs further study.
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