How does Adenomyosis cause pain?

 

In the ectopic lesions of Adenomyosis, there is estrogen synthesis and secretion, by using gonadotropin to release hormones to cause low estrogen status, it can control the development of the disease and make dysmenorrhea disappear, this might indicate that adenomyosis pain is related to estrogen.  

 

Adenomyosis is an estrogen-dependent disease in which estrogen persists in women and stimulates the development and progression of Adenomyosis.  Abnormal expression of aromatase in Adenomyosis lesions leads to an increase in local estrogen.  Estrogen promotes endometrial division, which promotes the implantation, growth and development of ectopic lesions in the myometrium. The periodic changes lead to local hemorrhage, which causes the uterus to enlarge and dysmenorrhea.

 

Hypertonic contractions of the uterus can also cause dysmenorrhea. Estrogen can promote uterine contractions and coordinate with oxytocin to regulate uterine movement. Estrogen also increases the frequency and duration of uterine contractions. In addition to estrogen and oxytocin, prostaglandins are also important factors in regulating uterine contractions.  And estrogen can regulate the production of prostaglandin products.

 

In addition, medical research has confirmed that there are nerve fibers in endometriotic lesions, abdominal adhesions, and myometrium.  Ectopic endometrial secretion of nerve growth factor may lead to local nerve fiber growth, these nerve fibers play an important role in the conduction of pain.

 

The study found that the deeper the endometrial invasion, the more small vesicles of Adenomyosis.  In addition, the range of dysmenorrhea, pelvic pain and adenomyosis is proportional, and the extent of the lesion is determined by the proportion of small vesicles.  Deep invasion affects uterine contractions, leading to dysmenorrhea and pelvic pain.  Therefore, the severity of dysmenorrhea is related to the depth of invasion and also to the location of the lesion.  This is also why some patients with adenomyosis have severe dysmenorrhea, while some patients have mild or no dysmenorrhea.

 

 

The relationship between nerve growth factor and adenomyosis pain?

 

The clinical symptoms of pelvic pain caused by Adenomyosis have seriously affected women's daily work and life.  Asr clinical cases confirmed, the current effective cure is to take TCM formula Fuyan Pill, activating blood circulation, eliminating phlegm and stasis, and calming the pain. It can completely cure without recurrence.  Because the ingredients are natural, chemical-free, non-resistance, and no side effects, the majority of female friends can take it with confidence.